Description
Product Characteristics:
Equilibrative nucleoside transporters (ENTs) regulate many physiological processes and are widely distributed in mammals, plants, yeasts, insects, nematodes and protozoans. They enable facilitated diffusion of hydrophilic nucleosides, such as adenosine and nucleoside analogs, across cell membranes. ENTs are required for uptake of antiviral and anticancer nucleoside drugs and influence a variety of physiological processes, such as neurotransmission and platelet aggregation, by regulating the amount of adenoside available to cell surface receptors. Equilibrative nucleoside transporter 2 (ENT2), also designated solute carrier family 29 (nucleoside transporters), member 2, belongs to the SLC29A transporter family and is a mammalian ENT isoform. ENT2 mediates the equilibrative transport of hypoxanthine in addition to nucleosides and is purine-selective.
Subcellular location: Nucleus, Cell membrane
Synonyms: DER12, Equilibrative NBMPR-insensitive nucleoside transporter, Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter, Equilibrative nucleoside transporter 2, HNP36, Hydrophobic nucleolar protein, 36 kDa, SLC29A2, solute carrier family 29 nucleoside transporters, member 29, Solute carrier family 29 member 2, S29A2_HUMAN.
Target Information: The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]